Figure 1.
Natural EPAC agonist cAMP compared to the EPAC1-selective chlorothiophenyl analogue 007 and its acetoxymethyl ester 007-AM which displays increased cell permeability. Also shown are the EPAC2-selective thiobenzyl thiophosphates S-220 and S-223.
Extant cyclic nucleotide EPAC agonists.

Natural EPAC agonist cAMP compared to the EPAC1-selective chlorothiophenyl analogue 007 and its acetoxymethyl ester 007-AM which displays increased cell permeability. Also shown are the EPAC2-selective thiobenzyl thiophosphates S-220 and S-223.

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