SD rats were immunized by a single intradermal injection of 0.1 ml FCA into the left hind paw to establish the AIA model. Immunized rats received FM0807 (0.1 or 0.2 mmol.kg⁻¹ per day), curcumin (0.1 mmol.kg⁻¹ per day) or vehicle by gastric gavage daily from day 7 to 21. A group of immunized rats receiving aspirin (0.1 mmol.kg⁻¹ per day) during the same period served as positive controls. Clinical evaluation was performed prior to immunization (baseline) and on alternate days after the initiation of FM0807/Cur/Aspirin treatment (post-dosing) up to 21 days through standardized scoring of arthritis (A), measurement of edema (B,C). The results are shown as mean ± SD; n=8 per group. *P<0.05, **P<0.01, ***P<0.001 vs. the vehicle control; ^###P<0.001 vs. the normal control; ^∇P<0.05, ^∇∇P<0.01 vs. the aspirin group. Data were analyzed using one-way ANOVA, followed by t test.