Domain architecture of representative SNXs in different subfamilies
All SNXs share a conserved PX domain. Other domain structures of SNXs in different subfamilies are also indicated. BAR, Bin/Amphiphysin/Rvs domain; FERM, protein 4.1/ezrin/radixin/moesin domain; FHA, forkhead associated domain; KM, kinesin motor domain; MIT, microtubule interacting and trafficking domain; PDZ, postsynaptic density 95/discs large/zonula occludens domain; PX, phagocyte oxidase (phox) homology domain; PXA, PX-associated domain A; PXC, PX-associated domain C; RB, Rab5-binding domain; RGS, regulator of G-protein signaling domain; SNX, sorting nexin.