(A) Representative images of HE staining of kidney cortex and medulla junction. (B) Representative photomicrographs of Von Kossa staining of calcium deposition and immunostaining of OPN and CD44 expression. The crystal deposition was clearly increased in the oxalate mouse group. After the FFJQC treatment, the crystal deposition was decreased significantly in this group. The protein expression levels of OPN and CD44 were increased in the oxalate group, then their levels were decreased significantly after the FFJQC treatment. (C) Tubulointerstitial damage were assessed semiquantitatively according to Carraway’s scoring from every 20 random views. (D) Semi-quantitative analysis of calcium deposition in the area of positive staining from 20 random views. (E,F) Semi-quantitative analysis of OPN and CD44 expression in each group from 20 random immunohistochemical views. (C) **P<0.0001 Oxalate group compared with Saline group, ^##P=0.002 FFJQC group compared with Oxalate group. (D) **P<0.0001 Oxalate group compared with Saline group, ^##P<0.0001 FFJQC group compared with Oxalate group. (E) **P<0.0001 Oxalate group compared with Saline group, ^##P<0.0001 FFJQC group compared with Oxalate group. (F) **P<0.0001 Oxalate group compared with Saline group, ^##P<0.0001 FFJQC group compared with Oxalate group.