Altered neutrophil reactivity in PMR patients during steroid therapy
Neutrophils from PMR patients were isolated at 1-, 12- and 24-week post-steroid treatment and flowed over activated HUVEC monolayers under shear stress. Cells from age-matched control volunteers were also used. Parameters measured include: total cell capture (A); total cell rolling (B) and total cell firm adhesion of neutrophils (C). Representative images are shown in (D). Dotted lines refer to age-mated control. Data are mean ± S.E.M. of n=10 per time-point. **P<0.01 compared with age-matched control (n=9); ##P<0.001 compared with week 12. One-way ANOVA, Bonferroni post-correction, repeated measures.