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Figure 1

(A) Chemical structure of Curcumin; (B) chemical structure of aspirin; (C) chemical structure of curcumin analog FM0807. Molecular formula: C28H24O8, molecular weight: 488.15 g.mol−1; (D) viability of RAW 264.7 after treatment of different concentrations of FM0807. At a given concentration, FM0807, had no significant effect on the cellular activity of RAW 264.7 compared with the control group; (E) the release of TNF-α; (F) the release of IL-1β; (G) the release of IL-6; (H) the release of nitrite. Values were mean ± S.D. (n=3); **P<0.01 compared with the control group; #P<0.01 and ##P<0.05 compared with the LPS-treated group. Abbreviations: IL, interleukin, LPS, lipopolysaccharide, TNF-α, tumor necrosis factor-α.

Chemical structures of Cur, aspirin, and FM0807 and inhibitory effects of FM0807 on LPS-induced cytokines

(A) Chemical structure of Curcumin; (B) chemical structure of aspirin; (C) chemical structure of curcumin analog FM0807. Molecular formula: C₂₈H₂₄O₈, molecular weight: 488.15 g.mol⁻¹; (D) viability of RAW 264.7 after treatment of different concentrations of FM0807. At a given concentration, FM0807, had no significant effect on the cellular activity of RAW 264.7 compared with the control group; (E) the release of TNF-α; (F) the release of IL-1β; (G) the release of IL-6; (H) the release of nitrite. Values were mean ± S.D. (n=3); **P<0.01 compared with the control group; ^#P<0.01 and ^##P<0.05 compared with the LPS-treated group. Abbreviations: IL, interleukin, LPS, lipopolysaccharide, TNF-α, tumor necrosis factor-α.

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