Cells (uninfected or infected with 150 MOI No-As or AS-Atf3) were unstimulated or exposed to ET-1 for 90 min and RNA expression profiles determined using Affymetrix rat exon 1.0 ST arrays. (A) Heatmaps show expression profiles for probesets that were significantly changed (>1.5-fold, FDR<0.05) by viral infection alone. Normalization is to the gene median [range is −2.5 (cyan) through 0 (black) to +2.5 (red) on a log₂ scale]. Results are means for three hybridizations each representing three independent myocyte preparations. Clustering on conditions and entities used a Euclidean distance matrix and centroid linkage ratio. (B) Transcripts were classified according to function. Up- and down-regulated transcripts are in red and blue respectively. Transcripts regulated by interferons (Ifn) in other systems are in lighter colours.