Foldamers inhibit Aβ42 and Aβ43 fibrillization under different assembly conditions
Aβ42 or Aβ43 (5 μM) were incubated with agitation for 16 h at 25°C without or with Aβ42 fibril seed or Aβ43 fibril seed (0.1 μM monomer) plus or minus 20 μM (Arg-Benz)4-CONH2, (Arg-Sal)3-(Cit-Sal)-CONH2, Sal-(Lys-Sal)3-CONH2, Ac-Sal-(Lys-Sal)3-CONH2 or (Cit-Sal)4-CONH2. Fibrillization was assessed by ThT fluorescence. Values represent means±S.E.M. (n=3).