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Figure 2

Three-letter amino acid nomenclature is used to indicate the side chain (Lys, Arg or Cit) and the Sal or Benz backbone is indicated. N- (Ac) and C- (NH2, OH, OMe or β-Ala) terminal groups are also indicated. Foldamers that inhibit spontaneous Aβ42 and Aβ43 fibrillization, (Arg-Benz)4-CONH2 and (Arg-Sal)3-(Cit-Sal)-CONH2, are boxed in black. Foldamers that inhibit spontaneous Aβ42 fibrillization but not spontaneous Aβ43 fibrillization, Sal-(Lys-Sal)3-CONH2 and Ac-Sal-(Lys-Sal)3-CONH2, are boxed in grey.

Nomenclature and structure of aromatic foldamers

Three-letter amino acid nomenclature is used to indicate the side chain (Lys, Arg or Cit) and the Sal or Benz backbone is indicated. N- (Ac) and C- (NH₂, OH, OMe or β-Ala) terminal groups are also indicated. Foldamers that inhibit spontaneous Aβ42 and Aβ43 fibrillization, (Arg-Benz)₄-CONH₂ and (Arg-Sal)₃-(Cit-Sal)-CONH₂, are boxed in black. Foldamers that inhibit spontaneous Aβ42 fibrillization but not spontaneous Aβ43 fibrillization, Sal-(Lys-Sal)₃-CONH₂ and Ac-Sal-(Lys-Sal)₃-CONH₂, are boxed in grey.

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