The endolysosomal system and its connections to RTKs and autophagy
Following ligand binding, RTKs can undergo clathrin-mediated endocytosis. These vesicles mature into early endosomal populations and can be sorted into either late endosome-lysosome compartment for degradation or recycling endosomes and delivered back to plasma membrane. Autophagy-related proteins overlap with many of these endosomal compartments which are required for autophagosome biogenesis and lysosomal fusion.