Role of glutamate inhibition in mediating effects of PE medium on mixed cortical cultures
Mixed cortical cultures were incubated with NMDA receptor antagonist MK801 prior to exposure to culture medium conditioned by healthy (n=6) or preeclamptic (n=6) placental explants that had been treated with no NPs or with MitoQ-NPs. Lengths of neuronal dendrites (A), lengths of TH+ cell processes (B) and levels of glutamate receptor subunit GluN1 (C) were measured in the cortical cultures (data are presented as means + S.E.M.; ***P<0.001).