Inhibition of mTORc1 kinase activity results in the activation of ULK1 and consequent induction of macroautophagy. Inhibition of LRRK2 kinase activity leads to increase in the production of autophagosomes by activation of an unknown effector which is not ULK1. Prolonged inhibition of LRRK2 kinase and/or a chronic excess in macroautophagy induction activate a feedback loop responsible for repression of ULK1 by means of activation of an unknown kinase which is not mTOR.