(i) The CMA motif may contain up to two hydrophobic residues [isoleucine (I), phenylalanine (F), leucine (L) or valine (V)], up to two positive residues [arginine (R) or lysine (K)] and a single negatively charged residue [glutamate (E) or aspartate (D)] flanked at either the N- or C-terminus of the pentapeptide by a single glutamine (Q) residue. This is often referred to as a KFERQ or KFERQ-like motif [12]. (ii) Protein sequence of α-synuclein highlighting the CMA motif (bold and underlined) and potential CMA-targeting motif residues.