(i) Misfolded plasma membrane proteins can be tagged for degradation via the E3 ubiquitin ligase CHIP. The resultant ubiquitinated proteins are endocytosed into early endosomes, which mature into late endosomes. The misfolded plasma membrane proteins are then delivered to lysosomes via the fusion of late endosomes with this organelle. (ii) Macroautophagy encapsulates cytoplasmic material, including soluble cytosolic proteins and protein aggregates, into double-membraned vesicles that then fuse with the lysosome. (iii) In CMA, the chaperone Hsc70 recognizes misfolded proteins and these are translocated into the lysosome by LAMP-2a. (iv) Microautophagy is associated with the formation of invaginations in the lysosomal membrane and could also contribute to the delivery of proteins into the lysosome. ER, endoplasmic reticulum. Adapted from [6,9].