The research route for exploiting lncRNAs in BAT adipogenesis contains four steps: 1, transcriptional profiling; 2, verifying lncRNAs; 3, functional study; and 4, mechanism exploring. Two examples for regulatory mechanisms of lncRNAs in BAT are presented (upper panel: Firre–hnRNPU interplay-mediated trans-chromosomal interactions promotes adipogenesis; lower panel: Blnc1 cis-regulates EBF2, and Blnc1–EBF2 forms a feedforward loop to promote brown/beige adipogenesis). iWAT, inguinal WAT.