(A) The three core transcriptional regulators of inducible brown fat, namely PRDM16, PPARγ and PGC-1α, are shown as ovals. Other transcriptional regulators are represented in a plain text format. A pointed arrow represents activation, whereas a blunt arrow represents inhibition. See text for detailed explanation of the relationship among the different regulators. Browning involves the repression of white-fat genes (B) and the induction of brown-fat genes (C) Illustrated is how some of the above-mentioned regulators come together to bring about such effects.