Figure 3
(A) Basal plasma aldosterone levels in male and female KO (KCNJ5−/−), heterozygous (KCNJ5+/−) and WT (KCNJ5+/+) mice (n=7). *P<0.05 compared with male WT, **P<0.05 compared with female WT. (B) Levels of Cyp11B2 expression in WT compared with KO male and female mice (n=4). (C) Levels of plasma aldosterone before and 30 mins after Ang-II in male and female KO (KCNJ5−/−) mice (n=4–7). *P<0.05 compared with basal, #P<0.05 male compared with female KO. Bars are mean ± S.E.M.
Differences in basal and Ang-II stimulated aldosterone levels and adrenal CYP11B2 gene expression in mice by genotype and sex.

(A) Basal plasma aldosterone levels in male and female KO (KCNJ5−/−), heterozygous (KCNJ5+/−) and WT (KCNJ5+/+) mice (n=7). *P<0.05 compared with male WT, **P<0.05 compared with female WT. (B) Levels of Cyp11B2 expression in WT compared with KO male and female mice (n=4). (C) Levels of plasma aldosterone before and 30 mins after Ang-II in male and female KO (KCNJ5−/−) mice (n=4–7). *P<0.05 compared with basal, #P<0.05 male compared with female KO. Bars are mean ± S.E.M.

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