Changes of profibrotic molecules in protein production in renal cortex tissue
Renal content of total TGFβ1(A) determined by ELISA and PAI-1 (B), FN (C), and Col I (D) determined by Western blot assay was significantly increased in both male and female transgenic (TG) rats fed with I3C for 4 weeks. Protein values of PAI-1, FN, and Col I are expressed relative to the wild-type (WT) control fed without I3C, which was set at unity. *P<0.05, compare with male WT rats fed without I3C. #P<0.05, compared with female WT rats fed without I3C. n=5/each group.