(A, B) Representative immunohistochemical MMP-11 staining of skin wound samples from diabetic (db+/db+) mice treated with vehicle (6 μl of 0.9% NaCl/mouse per day) or RLX (25 μg/mouse per day, subcutaneously) at day 12. Arrows indicate staining positivity. (C) Quantification of MMP-11 staining per field in normoglycaemic (db+/+m) and diabetic (db+/db+) mice treated with vehicle (6 μl of 0.9% NaCl/mouse per day) or with RLX (25 μg/mouse per day, subcutaneously) at day 12. Each bar represents the mean±S.D. of six animals. *P<0.05 compared with db+/+m+vehicle; #P<0.01 compared with db+/db++vehicle.