(A, B) Representative immunohistochemical VEGFR-2 staining of skin wounds samples from diabetic (db⁺/db⁺) mice treated with vehicle (6 μl of 0.9% NaCl/mouse per day) or RLX (25 μg/mouse per day, subcutaneously) at day 12. Arrows indicate staining positivity. (C, D) Representative immunohistochemical VE-cadherin staining of skin wounds samples from diabetic (db⁺/db⁺) mice treated with vehicle (6 μl of 0.9% NaCl/mouse per day) or RLX (25 μg/mouse per day, subcutaneously) at day 12. Arrows indicate staining positivity. (C, F) Quantification of VEGFR-2- and VE-Cadherin-positive cells per field in normoglycaemic (db^+/+m) and diabetic (db⁺/db⁺) mice treated with vehicle (6 μl of 0.9% NaCl/mouse per day) or with RLX (25 μg/mouse per day, subcutaneously) at day 12. Each bar represents the mean±S.D. of six animals. *P<0.05 compared with db^+/+m+vehicle; §P<0.01 compared with db^+/+m+vehicle; ^#P<0.01 compared with db⁺/db⁺+vehicle.