Time to complete the wound closure in normoglycaemic (db^+/+m) and diabetic (db⁺/db⁺) mice given either RLX (25 μg/mouse per day, subcutaneously) or vehicle (6 μl of 0.9% NaCl/mouse per day). Two additional groups of diabetic animals were administered with RLX (25 μg/mouse per day, subcutaneously) and treated with an anti-VEGF murine antibody (10 mg/kg of body weight, intraperitonealy daily) or with anti CXCR4 antibody (0.4 mg/kg of body weight, intraperitonealy daily). Each point represents the mean±S.D. of six animals. §P<0.001 compared with db^+/+m+vehicle or RLX; *P<0.05 compared with db^+/+m+vehicle; ^#P<0.001 compared with db⁺/db⁺+vehicle; °P<0.05 compared with db⁺/db⁺+RLX.