(A) Histological scores in wound samples collected from either normoglycaemic (db^+/+m) or diabetic mice (db⁺/db⁺) given either RLX (25 μg/mouse per day, subcutaneously) or vehicle (6 μl of 0.9% NaCl/mouse per day) at day 12. Each bar represents the mean±S.D. of six animals. §P<0.001 compared with db^+/+m+vehicle; ^#P<0.001 compared with db⁺/db⁺+vehicle. (B–E) Histological photomicrographs, haematoxylin–eosin, of the several experimental groups at day 12. (B) Vehicle-treated normoglycaemic (db^+/+m) wounds. Re-epithelialization is almost complete. Granulation tissue is well-formed without inflammatory infiltrates. (C) RLX-treated normoglycaemic (db^+/+m) wounds. Complete re-epithelialization and restoration of normal architecture in dermis. (D) Vehicle-treated diabetic (db⁺/db⁺) wounds. Incomplete re-epithelialization and poorly formed granulation tissue. (E) RLX-treated diabetic (db⁺/db⁺) wounds. Re-epithelialization is almost complete, well-organized granulation tissue and no evidence of inflammation, oedema or erythrorrhagies.