Sources of AA for eicosanoid biosynthesis in human MC LDs
MC LDs contain two major sources of AA: PLs as constituents of the LD surface monolayer and TAGs in the core of the LD. Phospholipases and triglyceride lipases mediate the liberation of AA from these two precursor pools to provide substrate for the biosynthesis of eicosanoids (PGs, LTs, HPETEs, EETs and HETEs) via three major pathways mediated by COXs, LOs and cytochrome P450 enzymes (P450). For further details, please refer to the text.