Genes of the mitochondrial function pathway differentially expressed between (upper boxes) patients with CAD and healthy controls, and (lower boxes) patients with CAD before and after a cardiac rehabilitation exercise programme, following a CABG procedure
Upper boxes, up-regulation of genes in the mitochondrial function pathways in patients with CAD compared with healthy control subjects. Lower boxes, down-regulation of genes in the mitochondrial function pathways following the cardiac rehabilitation programme. All genes were differentially expressed in microarray experiments (for details see Supplementary Table S4 at http://www.clinsci.org/cs/119/cs1190335add.htm). P values and fold changes (FC) in the boxes refer to results from qRT-PCR experiments (for details see Figures S1 and S2 at http://www.clinsci.org/cs/119/cs1190335add.htm). NDUFA1 and CASP3 are predicted targets of hsa-miR-92a and hsa-miR-92b, whose expression was increased following the cardiac rehabilitation programme (see Figure 4).