The bars indicate the degree of significance (y-axis) to which a given pathway is differentially modulated. ‘Threshold’ indicates the minimally accepted significance level. (■) The relative proportion of constituent members of a pathway significantly differentially expressed. Oxidative phosphorylation and mitochondrial dysfunction pathways were found to be significantly and consistently regulated across both experimental groups. NFAT, nuclear factor of activated T-cells; LXR, liver X receptor; PI3K, phosphoinositide 3-kinase; PPAR, peroxisome-proliferator-activated receptor; PKR, double-stranded-RNA-dependent protein kinase; RAR, retinoic acid receptor; RXR, retinoid X receptor.