(A) Localization of GFP:Repo-Man (green) and MEL-28 (red) at the nuclear periphery of HeLa cells. (B) Electron microscopy image of Repo-Man cell line expressing the peripheral N-terminus domain fused to GFP. Immuno-electron microscopy was conducted using an anti-GFP antibody. The white arrow shows accumulation at the edge of the NPC and the black arrow shows accumulation on heterochromatin adjacent to the NE. N, nuclear compartment; C, Cytoplasm. Image provided by Martin W. Goldberg, Durham University, UK. (C) Localization of CIP2A (green); picture kindly provided by Prof Jukka Westermarck, University of Turku, Finland.