Figure 4.
![(A) Domain architecture of PR-DUB core subunits BAP1 and ASXL proteins, as well as the UCH-L5 and Rpn13 proteins, which form a homologous deubiquitinase complex. UCH: ubiquitin carboxyl hydrolase; ASCL: active site crossover loop; CC1: coiled-coil N-terminal strand; CC2: coiled-coil C-terminal strand; ULD: Uch37-like domain; CTE: C-terminal extension; HARE-HTH: HB1, ASXL1, Restriction Endonuclease Helix-Turn-Helix; DEUBAD: DEUbiquitinase Adaptor; PHD-like: atypical PHD finger; PRU: Plecktrin-like Receptor for Ubiquitin. (B) Structure of the UCH-L5/Rpn13/ubiquitin complex (PDB: 4UEL, [16]).](https://port.silverchair-cdn.com/port/content_public/journal/biochemsoctrans/45/1/10.1042_bst20160173/2/bst-2016-0173c_04.jpeg?Expires=1716992031&Signature=pm~38btG3rCguY2CbLndO9NiulBeoCu304wjA9CuplSiGFBgDP3lu1mVL4FQFgcmUya~iQfuYjglhClciRJYztBd9pKZaLg4R6jh2vsbYOjhvJj8RilR5yk-lze93-4zbv9EmIzpTbD1WNrwATl1T6Qs1gqiPp-UZR3-wQz649~KmF-GT1~5eYJZkcdM6Lf568jjSADRsWfORSHYRfAoGsM04tBpHR36hu9mpBewhm5~zABXWZFqs2w87kF7KDYgD2oDaMYetvcq4DbQGM-3ph60GTQq3rGk0edbgoLPmrk0a~eBQ2ELZ5HvezBuSUarhZ5ZcQ71FMRFiAPquQYd2Q__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The PR-DUB complex.
(A) Domain architecture of PR-DUB core subunits BAP1 and ASXL proteins, as well as the UCH-L5 and Rpn13 proteins, which form a homologous deubiquitinase complex. UCH: ubiquitin carboxyl hydrolase; ASCL: active site crossover loop; CC1: coiled-coil N-terminal strand; CC2: coiled-coil C-terminal strand; ULD: Uch37-like domain; CTE: C-terminal extension; HARE-HTH: HB1, ASXL1, Restriction Endonuclease Helix-Turn-Helix; DEUBAD: DEUbiquitinase Adaptor; PHD-like: atypical PHD finger; PRU: Plecktrin-like Receptor for Ubiquitin. (B) Structure of the UCH-L5/Rpn13/ubiquitin complex (PDB: 4UEL, [16]).
