Figure 1.
Targeting essential enzymes in Mycobacterium abscessus: Fragment hits for PurC (SAICAR Synthetase), an enzyme of de novo purine biosynthesis.
(A) Surface electrostatic representation of PurC in complex with ATP. (B) Fragments occupying the adenylyl pocket of PurC making strong polar contacts. Figure prepared using PyMOL and Maestro (Schrödinger, LLC).
