Control of Nrf2 activation by different E3 ubiquitin ligase complexes
Acronyms are defined throughout the text. When no longer targeted for degradation by E3 ubiquitin ligase complexes, Nrf2 activity is controlled mainly by its rate of transcription, with newly transcribed Nrf2 regulating gene expression. It is the Keap1–Cul3–Rbx1, Hrd1 E3 ubiquitin ligase and SCFβ-TrCP complexes, however that underlie the stress responsive nature of Nrf2 activity.