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Figure 1

(A) Dual signature motifs of ABHD2: The positions of the conserved GXSXG lipase and HXXXXD acyltransferase motifs in ABHD2 are indicated by triangles with the respective amino acid residue positions and the key amino acids involved in α/β hydrolase domain catalytic triad are represented with (*) mark. (B) Phylogenetic analysis using the maximum likelihood method: Molecular phylogenetic analysis was performed with the sequences of Abhd2 (mouse) gi|33333856, Abhd2 (rat) gi|157820401, CG3488/Abhd2 (D. melanogaster) gi|27923956, Abhd2 (A. thaliana) gi|15240586 and all 21 human (h) ABHD family proteins hAbhd1 gi|308153404, hAbhd2 gi|23397661, hAbhd3 gi|134035377, hAbhd4 gi|74762601, hAbhd5 gi|31542303, hAbhd6 gi|189027141, hAbhd7 gi|134035378, hAbhd8 gi|74732007, hAbhd9 gi|92095996, hAbhd10 gi|8923001, hAbhd11 gi|74751292, hAbhd12 gi|109689718, hAbhd12B gi|50401854, hAbhd13 gi|74749881, hAbhd14A gi|143955271, hAbhd14B gi|33991637, hAbhd15 gi|308153403, hAbhd16A gi|23813746, hAbhd16B gi|23813959, hAbhd17A gi|194306562, hAbhd17B gi|74746845.

Domain structure and phylogenetic analysis of Human ABHD2

(A) Dual signature motifs of ABHD2: The positions of the conserved GXSXG lipase and HXXXXD acyltransferase motifs in ABHD2 are indicated by triangles with the respective amino acid residue positions and the key amino acids involved in α/β hydrolase domain catalytic triad are represented with (*) mark. (B) Phylogenetic analysis using the maximum likelihood method: Molecular phylogenetic analysis was performed with the sequences of Abhd2 (mouse) gi|33333856, Abhd2 (rat) gi|157820401, CG3488/Abhd2 (D. melanogaster) gi|27923956, Abhd2 (A. thaliana) gi|15240586 and all 21 human (h) ABHD family proteins hAbhd1 gi|308153404, hAbhd2 gi|23397661, hAbhd3 gi|134035377, hAbhd4 gi|74762601, hAbhd5 gi|31542303, hAbhd6 gi|189027141, hAbhd7 gi|134035378, hAbhd8 gi|74732007, hAbhd9 gi|92095996, hAbhd10 gi|8923001, hAbhd11 gi|74751292, hAbhd12 gi|109689718, hAbhd12B gi|50401854, hAbhd13 gi|74749881, hAbhd14A gi|143955271, hAbhd14B gi|33991637, hAbhd15 gi|308153403, hAbhd16A gi|23813746, hAbhd16B gi|23813959, hAbhd17A gi|194306562, hAbhd17B gi|74746845.