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Table 2.

Recently reported structures of small molecule inhibitors of E3 ligases

Target	Compound ID	Structure	Reference
TRAF6	1, C25-140		Brenke et al. [62]
RNF4	2, TRH 1-23		Ward et al. [63]
RNF4	3, CCW16		Ward et al. [63]
VHL	4a: X = F, Z = H 4b: X = H, Z = F		Testa et al. [64]
WWP2	5		Watt et al. [65]
	6
	7
	8
	9
SMURF1	10, HS-152		Tian et al. [66]
HOIP	11, Bendamustine		De Cesare et al. [67]
	12		Johansson et al. [68]
	13
	14

Target	Compound ID	Structure	Reference
TRAF6	1, C25-140		Brenke et al. [62]
RNF4	2, TRH 1-23		Ward et al. [63]
RNF4	3, CCW16		Ward et al. [63]
VHL	4a: X = F, Z = H 4b: X = H, Z = F		Testa et al. [64]
WWP2	5		Watt et al. [65]
	6
	7
	8
	9
SMURF1	10, HS-152		Tian et al. [66]
HOIP	11, Bendamustine		De Cesare et al. [67]
	12		Johansson et al. [68]
	13
	14