A three-generation Chinese family with clear diagnosis of ADCC and myopia was identified (Figure 1). All affected individuals in this family had lamellar opacity cataracts (Figure 2) in total 11 family members (six affected and five unaffected) participated in the study (Table 2). The proband was a 16-year-old girl (III:7), whose vision had decreased since birth. She was diagnosed with bilateral cataract at the age of four and myopia at 7 years old. An affected member (III:6), the 22-year-old sister of the proband, was diagnosed with bilateral cataract and myopia at the age of seven, and underwent right eye’s cataract extraction at the age of ten. Another affected member (II:9), whose phenotype was similar with the proband, had obvious lamellar and cortical opacity. According to the medical records, other affected individuals diagnosed with bilateral lamellar cataract and myopia have been treated with cataract extraction in different years.