...Caroline Weglinski; Alexander Jeans The amyloid hypothesis, which proposes that accumulation of the peptide amyloid-β at synapses is the key driver of Alzheimer’s disease (AD) pathogenesis, has been the dominant idea in the field of Alzheimer’s research for nearly 30 years. Recently, however...

.... astrocytes glutamate receptor synapses thalamus The thalamus comprises over 30 distinct nuclei ( Figure 1 B) [ 1 ], with each nucleus governing the processing and relay of information to a discrete area of corresponding cerebral cortex. Information across all modalities, with the possible...

...Anna Sanchez Avila; Christopher M. Henstridge Synapses are minuscule, intricate structures crucial for the correct communication between neurons. In the 125 years since the term synapse was first coined, we have advanced a long way when it comes to our understanding of how they work and what...

... can be used to link genetic variability to neurobiological mechanisms and behavioral traits. Genetic factors associated with NDDs can be grouped functionally into common biological pathways, with one prominent functional group being genes associated with the synapse. These include the neuroligins...

... that ‘break’ the diffraction limit of conventional light microscopy, over the last decades has enabled researchers to reveal the nanoscopic synaptic environment. In this review, we highlight and discuss recent advances in our understanding of the nano-world of the so-called tripartite synapses...