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Helen A. Rowland, Samuel R. Moxon, Nicola J. Corbett, Kelsey Hanson, Kate Fisher, Katherine A.B. Kellett, Nigel M. Hooper
Neuronal Signal (2023) 7 (4): NS20230016.
Published: 03 October 2023
...)-derived cortical neurons. Using an Aβ fluorescence polarisation assay, inhibition of IDE but not of NEP, blocked the degradation of Aβ by human neurons. When the neurons were grown in a 3D extracellular matrix to visualise Aβ deposition, inhibition of IDE but not NEP, increased the number of Aβ deposits...
Neuronal Signal (2019) 3 (3): NS20180134.
Published: 11 September 2019
...Fumi Suomi; Thomas G. McWilliams Autophagy refers to the lysosomal degradation of damaged or superfluous components and is essential for metabolic plasticity and tissue integrity. This evolutionarily conserved process is particularly vital to mammalian post-mitotic cells such as neurons, which face...
Hannah Scott, Tom J. Phillips, Greer C. Stuart, Mark F. Rogers, Bruno R. Steinkraus, Simon Grant, C. Patrick Case
Neuronal Signal (2018) 2 (4): NS20180139.
Published: 12 October 2018
... from patients with preeclampsia secreted molecules that could affect cortical cells in culture. Application of culture medium conditioned by preeclamptic placentae to mixed cortical cultures caused changes in neurons and astrocytes that were related to key changes observed in brains of patients...
Includes: Supplementary data