... BY) . dopamine leucine rich repeat kinase neurodegeneration Parkinsons disease transgenic mice Parkinson’s disease (PD) is a progressive, multifactorial, multisystem and clinically heterogeneous motor disorder presenting with cardinal hypokinetic motor symptoms (typically akinesia/bradykinesia...

... published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Glaucoma is a disease of neurodegeneration of retinal ganglion cells (RGCs) [ 1 ]. The optic nerve comprises axons of these RGCs located primarily...

... brain barrier extracellular matrix induced pluripotent stem cells neurodegeneration stroke The use of hydrogels allows cells to be grown in a 3D environment and with appropriate mechanical, biophysical and biochemical properties that better replicates the in vivo architecture of the native...

... with neurodegeneration. Gain-of-function mutations in PKCα are associated with Alzheimer’s disease (AD) and mutations in PKCγ cause spinocerebellar ataxia (SCA) type 14 (SCA14). This article presents an overview of the role of the conventional PKCα and PKCγ in neurodegeneration and proposes repurposing PKC inhibitors...

... the recent research on neuronal α-klotho and discuss how the neuroprotective properties of α-klotho could be exploited to tackle age- and neurodegeneration-associated cognitive dysfunction. In human neuroblastoma SH-SY5Y cells exposed to amyloid-β, recombinant soluble klotho treatment led to down...

... and neurodegeneration in PD, and review the recent literature on SARS infections, the potential link with PD and the potential areas of study in the future. Correspondence: Declan P. McKernan ( declan.mckernan@nuigalway.ie ) 27 11 2020 30 03 2021 31 03 2021 09 04 2021 © 2021 The Author...

... by the participation of University College London in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. neurodegeneration neuroscience signalling Neuronal Signaling was launched in 2017 by the Biochemical Society...

... HD can be regarded as whole brain disease [ 13 , 16 ]. DNA synthesis and repair genome integrity mutation neurodegeneration The main purpose of this review is to provide an overview of recent developments in the role of DNA repair in Huntington’s disease (HD) and other triplet repeat...

... unique logistical challenges and must sustain homoeostasis over decades. Defective autophagy has pathophysiological importance, especially for human neurodegeneration. The present-day definition of autophagy broadly encompasses two distinct yet related phenomena: non-selective and selective autophagy...

... processes and the accumulation of dysfunctional mitochondria may be the main cause of neuronal death and lead to neurodegeneration. Here, we focus on the inseparable relationship of mitochondria dynamics and mitophagy and how their dysfunction may lead to neurodegenerative diseases. The MQC system plays...

... proteins, and their relevance in neurodegenerative pathologies. It also covers alterations to calcium homoeostasis in Friedreich ataxia (FA). calcium homoeostasis mitochondrial permeability transition pore mitochondria neurodegeneration Calcium is used in many cellular processes...

... phosphorylation of these substrates is the cause of the neurodegeneration in PD. In this review, we summarize latest findings regarding the physiological and pathological functions of LRRK2, and discuss the possible molecular mechanisms of neurodegeneration caused by LRRK2 and its substrates. Correspondence...

.... neurodegeneration neuroinflammation Parkinsons disease viral infection Parkinson’s disease (PD), the most common neurodegenerative motor disorder, is generally characterized by the selective degeneration of dopaminergic neurones in the substantia nigra pars compacta (SN) of the midbrain, resulting...

... is associated with neurodegeneration. This review presents an overview of signaling by diacylglycerol (DG)-dependent PKC isozymes in the brain, and focuses on the role of the Ca 2+ -sensitive conventional PKC isozymes in neurodegeneration. The balance between phosphorylation and dephosphorylation finely tunes...