... of WIN55,212-2 in the injection increased the remaining RGCs to ∼70%. In Figure 2 , intraocular injection of WIN55,212-2 protects RGCs from NMDA-induced neurodegeneration. In the same mouse, control eye is taken as 100% and is the eye injected with saline (saline). The eye with NMDA injected...

... products. Maintaining efficient cerebral blood flow (CBF), the integrity of the BBB and correct NVU function are imperative to sustain healthy brain function. blood brain barrier extracellular matrix induced pluripotent stem cells neurodegeneration stroke © 2021 The Author(s). 2021...

... with neurodegeneration. Gain-of-function mutations in PKCα are associated with Alzheimer’s disease (AD) and mutations in PKCγ cause spinocerebellar ataxia (SCA) type 14 (SCA14). This article presents an overview of the role of the conventional PKCα and PKCγ in neurodegeneration and proposes repurposing PKC inhibitors...

... the recent research on neuronal α-klotho and discuss how the neuroprotective properties of α-klotho could be exploited to tackle age- and neurodegeneration-associated cognitive dysfunction. In human neuroblastoma SH-SY5Y cells exposed to amyloid-β, recombinant soluble klotho treatment led to down...

... and neurodegeneration in PD, and review the recent literature on SARS infections, the potential link with PD and the potential areas of study in the future. Correspondence: Declan P. McKernan ( declan.mckernan@nuigalway.ie ) 27 11 2020 30 03 2021 31 03 2021 09 04 2021 © 2021 The Author...

... License 4.0 (CC BY) . Open access for this article was enabled by the participation of University College London in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. neurodegeneration neuroscience signalling...

... assessing disease progression [ 65 ] and CAG repeat instability in blood samples from patients [ 66 ]. DNA synthesis and repair genome integrity mutation neurodegeneration The main purpose of this review is to provide an overview of recent developments in the role of DNA repair in Huntington’s...

... unique logistical challenges and must sustain homoeostasis over decades. Defective autophagy has pathophysiological importance, especially for human neurodegeneration. The present-day definition of autophagy broadly encompasses two distinct yet related phenomena: non-selective and selective autophagy...

... processes and the accumulation of dysfunctional mitochondria may be the main cause of neuronal death and lead to neurodegeneration. Here, we focus on the inseparable relationship of mitochondria dynamics and mitophagy and how their dysfunction may lead to neurodegenerative diseases. The MQC system plays...

... and triggers cell death [ 21 ]. The central role of VDAC in neurodegeneration has been described in AD [ 22 , 23 ] and PD [ 24 ]. Although calcium enters the mitochondria through the VDAC [ 15 , 25 ], the channelling towards the mitochondrial matrix through the inner membrane is mainly accomplished...

... phosphorylation of these substrates is the cause of the neurodegeneration in PD. In this review, we summarize latest findings regarding the physiological and pathological functions of LRRK2, and discuss the possible molecular mechanisms of neurodegeneration caused by LRRK2 and its substrates. Correspondence...

... ]. Although these acute cases of viral infection did not present with classical PD, these findings (along with the believed EL association with PD) led to multiple clinical studies in the late 1970s and early 1980s investigating the relationship between viral infections and PD. neurodegeneration...

... is associated with neurodegeneration. This review presents an overview of signaling by diacylglycerol (DG)-dependent PKC isozymes in the brain, and focuses on the role of the Ca 2+ -sensitive conventional PKC isozymes in neurodegeneration. Alzheimer's disease neurodegeneration posttranslational...