...Richard Seager; Laura Lee; Jeremy M. Henley; Kevin A. Wilkinson Neurons are highly polarised, complex and incredibly energy intensive cells, and their demand for ATP during neuronal transmission is primarily met by oxidative phosphorylation by mitochondria. Thus, maintaining the health...

... article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy mitochondria neurodegeneration organelles neurons metabolism Membranous organelles make intimate contacts with each...

...Fei Gao; Jianmin Zhang Mitochondria homeostasis is sustained by the mitochondrial quality control (MQC) system, which is crucial for cellular health, especially in the maintenance of functional mitochondria. A healthy mitochondria network is essential for life as it regulates cellular metabolism...

...Elena Britti; Fabien Delaspre; Jordi Tamarit; Joaquim Ros Calcium is utilised by cells in signalling and in regulating ATP production; it also contributes to cell survival and, when concentrations are unbalanced, triggers pathways for cell death. Mitochondria contribute to calcium buffering...

... such as neurons. Beyond acting as cellular ‘power stations’ and initiators of apoptosis, neuronal mitochondria are highly mobile, transported to pre- and post-synaptic sites for rapid, localized ATP production, serve to buffer physiological and pathological calcium and contribute to dendritic arborization. Given...