... signalling pathways from the basal forebrain to the hippocampus and associated rhinal cortices, as well as changes in the microstructure of the hippocampus itself. In vivo behavioural and electrophysiological studies have shown that Ts65Dn animals have difficulties in spatial memory that mirror hippocampal...

... between microglia and neural precursor cells and could help us understand how inflammation, mediated by microglia, influences the development of new neurons in the adult hippocampus. Here, we put recent studies on TLX into the context of what is known about adult neurogenesis and microglial activation...

...Madhusmita Priyadarshini Sahu; Outi Nikkilä; Seija Lågas; Sulo Kolehmainen; Eero Castrén Primary neurons from rodent brain hippocampus and cortex have served as important tools in biomedical research over the years. However, protocols for the preparation of primary neurons vary, which often lead...

...Danka A. Kozareva; Gerard M. Moloney; Alan E. Hoban; Valerio Rossini; Ken Nally; John F. Cryan; Yvonne M. Nolan Microglia are an essential component of the neurogenic niche in the adult hippocampus and are involved in the control of neural precursor cell (NPC) proliferation, differentiation...