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Keywords: Parkinson's disease
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Articles
In Collection
Emerging technologies for research models of human neuronal disorders in vivo and in vitro
Journal:
Neuronal Signaling
Neuronal Signal (2021) 5 (4): NS20210026.
Published: 08 December 2021
...Joana Lama; Yazead Buhidma; Edward J.R. Fletcher; Susan Duty Parkinson’s disease (PD) is a complex, multisystem disorder characterised by α-synuclein (SNCA) pathology, degeneration of nigrostriatal dopaminergic neurons, multifactorial pathogenetic mechanisms and expression of a plethora of motor...
Articles
Journal:
Neuronal Signaling
Neuronal Signal (2021) 5 (3): NS20200083.
Published: 13 September 2021
...Shamma Qarin; Sarah K. Howlett; Joanne L. Jones; Roger A. Barker Dopaminergic (DA) cell replacement therapies are a promising experimental treatment for Parkinson’s disease (PD) and a number of different types of DA cell-based therapies have already been trialled in patients. To date, the most...
Articles
Journal:
Neuronal Signaling
Neuronal Signal (2021) 5 (3): NS20210028.
Published: 23 August 2021
...Sílvia Cabré; Verónica Alamilla; Niamh Moriarty; Abhay Pandit; Eilís Dowd In cell replacement approaches for Parkinson’s disease, the intracerebral implantation of dopamine neuron-rich grafts generates a neuroinflammatory response to the grafted cells that contributes to its varied outcome. Thus...
Articles
In Collection
Emerging technologies for research models of human neuronal disorders in vivo and in vitro
Journal:
Neuronal Signaling
Neuronal Signal (2021) 5 (2): NS20210021.
Published: 23 June 2021
...Jara M. Baena-Montes; Sahar Avazzadeh; Leo R. Quinlan α-synuclein is an increasingly prominent player in the pathology of a variety of neurodegenerative conditions. Parkinson’s disease (PD) is a neurodegenerative disorder that affects mainly the dopaminergic (DA) neurons in the substantia nigra...
Articles
In Collection
Coronavirus
Journal:
Neuronal Signaling
Neuronal Signal (2021) 5 (1): NS20200051.
Published: 16 April 2021
... many outstanding questions on whether the causative virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) can directly infect the central nervous system (CNS). Given the long association between viral infections with neurodegenerative conditions such as Parkinson’s disease (PD), it seems...
Articles
Journal:
Neuronal Signaling
Neuronal Signal (2017) 1 (2): NS20170027.
Published: 31 March 2017
...Gerard W. O'Keeffe; Shane V. Hegarty; Aideen M. Sullivan Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized by the degeneration of midbrain dopaminergic (mDA) neurons and their axons, and aggregation of α-synuclein, which leads to motor and late-stage...