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Keywords: Alzheimers disease
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Neuronal Signal (2023) 7 (4): NS20230016.
Published: 03 October 2023
...Helen A. Rowland; Samuel R. Moxon; Nicola J. Corbett; Kelsey Hanson; Kate Fisher; Katherine A.B. Kellett; Nigel M. Hooper Alzheimer’s disease (AD) is characterised by the aggregation and deposition of amyloid-β (Aβ) peptides in the human brain. In age-related late-onset AD, deficient degradation...
Neuronal Signal (2023) 7 (1): NS20220086.
Published: 06 January 2023
...Caroline Weglinski; Alexander Jeans The amyloid hypothesis, which proposes that accumulation of the peptide amyloid-β at synapses is the key driver of Alzheimer’s disease (AD) pathogenesis, has been the dominant idea in the field of Alzheimer’s research for nearly 30 years. Recently, however...
Neuronal Signal (2022) 6 (1): NS20210054.
Published: 08 April 2022
... of chromosome 21 (trisomy 21) and are more likely to develop early-onset Alzheimer’s disease (AD) than the general population. Changes in expression of human chromosome 21 (Hsa21)-encoded genes, such as amyloid precursor protein ( APP ), play an important role in the pathogenesis of AD in DS (DS-AD). However...
Neuronal Signal (2021) 5 (2): NS20200101.
Published: 14 June 2021
...Kelsey Hanson; Kate Fisher; Nigel M. Hooper Cognitive dysfunction is a key symptom of ageing and neurodegenerative disorders, such as Alzheimer’s disease (AD). Strategies to enhance cognition would impact the quality of life for a significant proportion of the ageing population. The α-klotho...