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Keywords: Alzheimers diseaseClose
Neuronal Signal (2023) 7 (1): NS20220086.
Published: 06 January 2023
...Caroline Weglinski; Alexander Jeans The amyloid hypothesis, which proposes that accumulation of the peptide amyloid-β at synapses is the key driver of Alzheimer’s disease (AD) pathogenesis, has been the dominant idea in the field of Alzheimer’s research for nearly 30 years. Recently, however...
In CollectionEmerging technologies for research models of human neuronal disorders in vivo and in vitro
Neuronal Signal (2022) 6 (1): NS20210054.
Published: 08 April 2022
... of chromosome 21 (trisomy 21) and are more likely to develop early-onset Alzheimer’s disease (AD) than the general population. Changes in expression of human chromosome 21 (Hsa21)-encoded genes, such as amyloid precursor protein ( APP ), play an important role in the pathogenesis of AD in DS (DS-AD). However...
Neuronal Signal (2021) 5 (2): NS20200101.
Published: 14 June 2021
...Kelsey Hanson; Kate Fisher; Nigel M. Hooper Cognitive dysfunction is a key symptom of ageing and neurodegenerative disorders, such as Alzheimer’s disease (AD). Strategies to enhance cognition would impact the quality of life for a significant proportion of the ageing population. The α-klotho...
Neuronal Signal (2019) 3 (4): NS20190068.
Published: 28 November 2019
...Thaddeus K. Weigel; Joshua A. Kulas; Heather A. Ferris Type 2 diabetes is associated with adverse central nervous system effects, including a doubled risk for Alzheimer’s disease (AD) and increased risk of cognitive impairment, but the mechanisms connecting diabetes to cognitive decline...