... Alzheimers disease amyloid beta induced pluripotent stem cells Modelling Alzheimer s disease in a Dish Dissecting Amyloid- Metabolism in Human Neurons Elizabeth Hill and Thomas J Cunningham MRC Prion Unit at UCL, Institute of Prion Diseases, Courtauld Building, London W1W 7FF, UK Abstract...

...Helen A. Rowland; Samuel R. Moxon; Nicola J. Corbett; Kelsey Hanson; Kate Fisher; Katherine A.B. Kellett; Nigel M. Hooper Alzheimer’s disease (AD) is characterised by the aggregation and deposition of amyloid-β (Aβ) peptides in the human brain. In age-related late-onset AD, deficient degradation...

...Caroline Weglinski; Alexander Jeans The amyloid hypothesis, which proposes that accumulation of the peptide amyloid-β at synapses is the key driver of Alzheimer’s disease (AD) pathogenesis, has been the dominant idea in the field of Alzheimer’s research for nearly 30 years. Recently, however...

... of chromosome 21 (trisomy 21) and are more likely to develop early-onset Alzheimer’s disease (AD) than the general population. Changes in expression of human chromosome 21 (Hsa21)-encoded genes, such as amyloid precursor protein ( APP ), play an important role in the pathogenesis of AD in DS (DS-AD). However...

...Kelsey Hanson; Kate Fisher; Nigel M. Hooper Cognitive dysfunction is a key symptom of ageing and neurodegenerative disorders, such as Alzheimer’s disease (AD). Strategies to enhance cognition would impact the quality of life for a significant proportion of the ageing population. The α-klotho...

...Thaddeus K. Weigel; Joshua A. Kulas; Heather A. Ferris Type 2 diabetes is associated with adverse central nervous system effects, including a doubled risk for Alzheimer’s disease (AD) and increased risk of cognitive impairment, but the mechanisms connecting diabetes to cognitive decline...