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Keywords: Alzheimers disease
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Articles

Amyloid-β in Alzheimer’s disease – front and centre after all?

Caroline Weglinski, Alexander Jeans
Journal: Neuronal Signaling
Neuronal Signal (2023) 7 (1): NS20220086.
DOI: https://doi.org/10.1042/NS20220086
Published: 06 January 2023
...Caroline Weglinski; Alexander Jeans The amyloid hypothesis, which proposes that accumulation of the peptide amyloid-β at synapses is the key driver of Alzheimer’s disease (AD) pathogenesis, has been the dominant idea in the field of Alzheimer’s research for nearly 30 years. Recently, however...
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Articles

Cell models for Down syndrome-Alzheimer’s disease research

In Collection
Emerging technologies for research models of human neuronal disorders in vivo and in vitro
Yixing Wu, Nicole R. West, Anita Bhattacharyya, Frances K. Wiseman
Journal: Neuronal Signaling
Neuronal Signal (2022) 6 (1): NS20210054.
DOI: https://doi.org/10.1042/NS20210054
Published: 08 April 2022
... of chromosome 21 (trisomy 21) and are more likely to develop early-onset Alzheimer’s disease (AD) than the general population. Changes in expression of human chromosome 21 (Hsa21)-encoded genes, such as amyloid precursor protein ( APP ), play an important role in the pathogenesis of AD in DS (DS-AD). However...
View article titled, Cell models for Down syndrome-<span class="search-highlight">Alzheimer’s</span> <span class="search-highlight">disease</span> research
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Articles

Exploiting the neuroprotective effects of α-klotho to tackle ageing- and neurodegeneration-related cognitive dysfunction

Kelsey Hanson, Kate Fisher, Nigel M. Hooper
Journal: Neuronal Signaling
Neuronal Signal (2021) 5 (2): NS20200101.
DOI: https://doi.org/10.1042/NS20200101
Published: 14 June 2021
...Kelsey Hanson; Kate Fisher; Nigel M. Hooper Cognitive dysfunction is a key symptom of ageing and neurodegenerative disorders, such as Alzheimer’s disease (AD). Strategies to enhance cognition would impact the quality of life for a significant proportion of the ageing population. The α-klotho...
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Articles

Oxidized cholesterol species as signaling molecules in the brain: diabetes and Alzheimer’s disease

Thaddeus K. Weigel, Joshua A. Kulas, Heather A. Ferris
Journal: Neuronal Signaling
Neuronal Signal (2019) 3 (4): NS20190068.
DOI: https://doi.org/10.1042/NS20190068
Published: 28 November 2019
...Thaddeus K. Weigel; Joshua A. Kulas; Heather A. Ferris Type 2 diabetes is associated with adverse central nervous system effects, including a doubled risk for Alzheimer’s disease (AD) and increased risk of cognitive impairment, but the mechanisms connecting diabetes to cognitive decline...
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