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Molecular Bases of Health & Disease
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Articles

Modelling Alzheimer’s disease in a Dish – Dissecting Amyloid-β Metabolism in Human Neurons

Elizabeth Hill, Thomas J Cunningham
Journal: Neuronal Signaling
Neuronal Signal (2023) NS20230020.
https://doi.org/10.1042/NS20230020
Published: 28 November 2023
View article titled, Modelling Alzheimer’s disease in a Dish – Dissecting Amyloid-β Metabolism in Human Neurons
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Articles

Inflammation and emotion regulation: a narrative review of evidence and mechanisms in emotion dysregulation disorders

Flavia Petruso, Alexis E. Giff, Beatrice A. Milano, Maurilio Menduni De Rossi, Luigi Francesco Saccaro
Journal: Neuronal Signaling
Neuronal Signal (2023) 7 (4): NS20220077.
https://doi.org/10.1042/NS20220077
Published: 15 November 2023
View article titled, Inflammation and emotion regulation: a narrative review of evidence and mechanisms in emotion dysregulation disorders
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Articles

Modeling Parkinson’s disease in LRRK2 rodents

Chiara Domenicale, Stefano Magnabosco, Michele Morari
Journal: Neuronal Signaling
Neuronal Signal (2023) 7 (3): NS20220040.
https://doi.org/10.1042/NS20220040
Published: 16 August 2023
View article titled, Modeling Parkinson’s disease in LRRK2 rodents
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Articles

Inflammation in the pathogenesis of depression: a disorder of neuroimmune origin

Myles Corrigan, Aoife M. O'Rourke, Barry Moran, Jean M. Fletcher, Andrew Harkin
Journal: Neuronal Signaling
Neuronal Signal (2023) 7 (2): NS20220054.
https://doi.org/10.1042/NS20220054
Published: 13 July 2023
View article titled, Inflammation in the pathogenesis of depression: a disorder of neuroimmune origin
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Articles

Maternal immune activation and role of placenta in the prenatal programming of neurodevelopmental disorders

Rebecca M. Woods, Jarred M. Lorusso, Jennifer Fletcher, Heidi ElTaher, Francesca McEwan, Isabella Harris, Hager M. Kowash, Stephen W. D'Souza, Michael Harte, Reinmar Hager, Jocelyn D. Glazier
Journal: Neuronal Signaling
Neuronal Signal (2023) 7 (2): NS20220064.
https://doi.org/10.1042/NS20220064
Published: 31 May 2023
View article titled, Maternal immune activation and role of placenta in the prenatal programming of neurodevelopmental disorders
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Articles

Amyloid-β in Alzheimer’s disease – front and centre after all?

Caroline Weglinski, Alexander Jeans
Journal: Neuronal Signaling
Neuronal Signal (2023) 7 (1): NS20220086.
https://doi.org/10.1042/NS20220086
Published: 06 January 2023
View article titled, Amyloid-β in Alzheimer’s disease – front and centre after all?
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Articles

The role of thalamic group II mGlu receptors in health and disease

In Collection
Celebrating 125 years of the Synapse
Caroline S. Copeland, Thomas E. Salt
Journal: Neuronal Signaling
Neuronal Signal (2022) 6 (4): NS20210058.
https://doi.org/10.1042/NS20210058
Published: 15 November 2022
View article titled, The role of thalamic group II mGlu receptors in health and disease
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Articles

Neuroligins in neurodevelopmental conditions: how mouse models of de novo mutations can help us link synaptic function to social behavior

In Collection
Emerging technologies for research models of human neuronal disorders in vivo and in vitro , Celebrating 125 years of the Synapse
Tobias T. Pohl, Hanna Hörnberg
Journal: Neuronal Signaling
Neuronal Signal (2022) 6 (2): NS20210030.
https://doi.org/10.1042/NS20210030
Published: 10 May 2022
View article titled, Neuroligins in neurodevelopmental conditions: how mouse models of de novo mutations can help us link synaptic function to social behavior
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Articles

Neuroprotection of retinal ganglion cells in vivo using the activation of the endogenous cannabinoid signaling system in mammalian eyes

Greg Maguire, Christy Eubanks, George Ayoub
Journal: Neuronal Signaling
Neuronal Signal (2022) 6 (1): NS20210038.
https://doi.org/10.1042/NS20210038
Published: 16 February 2022
View article titled, Neuroprotection of retinal ganglion cells in vivo using the activation of the endogenous cannabinoid signaling system in mammalian eyes
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Articles

Cholinergic blockade of neuroinflammation: from tissue to RNA regulators

Tamara Zorbaz, Nimrod Madrer, Hermona Soreq
Journal: Neuronal Signaling
Neuronal Signal (2022) 6 (1): NS20210035.
https://doi.org/10.1042/NS20210035
Published: 11 February 2022
View article titled, Cholinergic blockade of neuroinflammation: from tissue to RNA regulators
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Articles

Animal models of Parkinson’s disease: a guide to selecting the optimal model for your research

In Collection
Emerging technologies for research models of human neuronal disorders in vivo and in vitro
Joana Lama, Yazead Buhidma, Edward J.R. Fletcher, Susan Duty
Journal: Neuronal Signaling
Neuronal Signal (2021) 5 (4): NS20210026.
https://doi.org/10.1042/NS20210026
Published: 08 December 2021
View article titled, Animal models of Parkinson’s disease: a guide to selecting the optimal model for your research
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Articles

Molecular mechanisms of action of stimulant novel psychoactive substances that target the high-affinity transporter for dopamine

Michelle A. Sahai, Jolanta Opacka-Juffry
Journal: Neuronal Signaling
Neuronal Signal (2021) 5 (4): NS20210006.
https://doi.org/10.1042/NS20210006
Published: 17 November 2021
View article titled, Molecular mechanisms of action of stimulant novel psychoactive substances that target the high-affinity transporter for dopamine
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Articles

3D hydrogel models of the neurovascular unit to investigate blood–brain barrier dysfunction

In Collection
Emerging technologies for research models of human neuronal disorders in vivo and in vitro
Geoffrey Potjewyd, Katherine A.B. Kellett, Nigel M. Hooper
Journal: Neuronal Signaling
Neuronal Signal (2021) 5 (4): NS20210027.
https://doi.org/10.1042/NS20210027
Published: 09 November 2021
View article titled, 3D hydrogel models of the neurovascular unit to investigate blood–brain barrier dysfunction
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Articles

Super-resolution imaging to reveal the nanostructure of tripartite synapses

Natalija Aleksejenko, Janosch P. Heller
Journal: Neuronal Signaling
Neuronal Signal (2021) 5 (4): NS20210003.
https://doi.org/10.1042/NS20210003
Published: 14 October 2021
View article titled, Super-resolution imaging to reveal the nanostructure of tripartite synapses
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Articles

Conventional protein kinase C in the brain: repurposing cancer drugs for neurodegenerative treatment?

Gema Lordén, Alexandra C. Newton
Journal: Neuronal Signaling
Neuronal Signal (2021) 5 (4): NS20210036.
https://doi.org/10.1042/NS20210036
Published: 08 October 2021
View article titled, Conventional protein kinase C in the brain: repurposing cancer drugs for neurodegenerative treatment?
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Articles

Mitochondrial and metabolic dysfunction in Friedreich ataxia: update on pathophysiological relevance and clinical interventions

David R. Lynch, Garrett Farmer
Journal: Neuronal Signaling
Neuronal Signal (2021) 5 (2): NS20200093.
https://doi.org/10.1042/NS20200093
Published: 17 May 2021
View article titled, Mitochondrial and metabolic dysfunction in Friedreich ataxia: update on pathophysiological relevance and clinical interventions
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Articles

The life cycle of voltage-gated Ca 2+ channels in neurons: an update on the trafficking of neuronal calcium channels

Laurent Ferron, Saloni Koshti, Gerald W. Zamponi
Journal: Neuronal Signaling
Neuronal Signal (2021) 5 (1): NS20200095.
https://doi.org/10.1042/NS20200095
Published: 23 February 2021
View article titled, The life cycle of voltage-gated Ca 2+ channels in neurons: an update on the trafficking of neuronal calcium channels
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Articles

Exercise alters LPS-induced glial activation in the mouse brain

Bibiana C. Mota, Áine M. Kelly
Journal: Neuronal Signaling
Neuronal Signal (2020) 4 (4): NS20200003.
https://doi.org/10.1042/NS20200003
Published: 02 December 2020
View article titled, Exercise alters LPS-induced glial activation in the mouse brain
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Articles

New developments in Huntington’s disease and other triplet repeat diseases: DNA repair turns to the dark side

Robert S. Lahue
Journal: Neuronal Signaling
Neuronal Signal (2020) 4 (4): NS20200010.
https://doi.org/10.1042/NS20200010
Published: 16 November 2020
View article titled, New developments in Huntington’s disease and other triplet repeat diseases: DNA repair turns to the dark side
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Articles

The class II histone deacetylases as therapeutic targets for Parkinson’s disease

Martina Mazzocchi, Louise M Collins, Aideen M. Sullivan, Gerard W. O'Keeffe
Journal: Neuronal Signaling
Neuronal Signal (2020) 4 (2): NS20200001.
https://doi.org/10.1042/NS20200001
Published: 09 June 2020
View article titled, The class II histone deacetylases as therapeutic targets for Parkinson’s disease
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Articles

Oxidized cholesterol species as signaling molecules in the brain: diabetes and Alzheimer’s disease

Thaddeus K. Weigel, Joshua A. Kulas, Heather A. Ferris
Journal: Neuronal Signaling
Neuronal Signal (2019) 3 (4): NS20190068.
https://doi.org/10.1042/NS20190068
Published: 28 November 2019
View article titled, Oxidized cholesterol species as signaling molecules in the brain: diabetes and Alzheimer’s disease
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Articles

The role of APOE4 in Alzheimer’s disease: strategies for future therapeutic interventions

Holly C. Hunsberger, Priyanka D. Pinky, Warren Smith, Vishnu Suppiramaniam, Miranda N. Reed
Journal: Neuronal Signaling
Neuronal Signal (2019) 3 (2): NS20180203.
https://doi.org/10.1042/NS20180203
Published: 18 April 2019
View article titled, The role of APOE4 in Alzheimer’s disease: strategies for future therapeutic interventions
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Articles

Modulation of CRMP2 via ( S )-Lacosamide shows therapeutic promise but is ultimately ineffective in a mouse model of CLN6-Batten disease

Katherine A. White, Jacob T. Cain, Helen Magee, Seul Ki Yeon, Ki Duk Park, Rajesh Khanna, Jill M. Weimer
Journal: Neuronal Signaling
Neuronal Signal (2019) 3 (2): NS20190001.
https://doi.org/10.1042/NS20190001
Published: 08 April 2019
View article titled, Modulation of CRMP2 via ( S )-Lacosamide shows therapeutic promise but is ultimately ineffective in a mouse model of CLN6-Batten disease
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Articles

Mitochondrial quality control and neurodegenerative diseases

Fei Gao, Jianmin Zhang
Journal: Neuronal Signaling
Neuronal Signal (2018) 2 (4): NS20180062.
https://doi.org/10.1042/NS20180062
Published: 03 December 2018
View article titled, Mitochondrial quality control and neurodegenerative diseases
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Articles

Mitochondrial calcium signalling and neurodegenerative diseases

Elena Britti, Fabien Delaspre, Jordi Tamarit, Joaquim Ros
Journal: Neuronal Signaling
Neuronal Signal (2018) 2 (4): NS20180061.
https://doi.org/10.1042/NS20180061
Published: 16 November 2018
View article titled, Mitochondrial calcium signalling and neurodegenerative diseases
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Articles

Preeclamptic placentae release factors that damage neurons: implications for foetal programming of disease

Hannah Scott, Tom J. Phillips, Greer C. Stuart, Mark F. Rogers, Bruno R. Steinkraus, Simon Grant, C. Patrick Case
Journal: Neuronal Signaling
Neuronal Signal (2018) 2 (4): NS20180139.
https://doi.org/10.1042/NS20180139
Published: 12 October 2018
View article titled, Preeclamptic placentae release factors that damage neurons: implications for foetal programming of disease
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Includes: Supplementary data
Articles

Physiological and pathological functions of LRRK2: implications from substrate proteins

In Collection
Protein structure and function
Miho Araki, Genta Ito, Taisuke Tomita
Journal: Neuronal Signaling
Neuronal Signal (2018) 2 (4): NS20180005.
https://doi.org/10.1042/NS20180005
Published: 10 October 2018
View article titled, Physiological and pathological functions of LRRK2: implications from substrate proteins
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Articles

A novel variant in TAF1 affects gene expression and is associated with X-linked TAF1 intellectual disability syndrome

Sarah E. Hurst, Erika Liktor-Busa, Aubin Moutal, Sara Parker, Sydney Rice, Szabolcs Szelinger, Grant Senner, Michael F. Hammer, Laurel Johnstone, Keri Ramsey, Vinodh Narayanan, Samantha Perez-Miller, May Khanna, Heather Dahlin, Karen Lewis, David Craig, Edith H. Wang, Rajesh Khanna, Mark A. Nelson
Journal: Neuronal Signaling
Neuronal Signal (2018) 2 (3): NS20180141.
https://doi.org/10.1042/NS20180141
Published: 16 July 2018
View article titled, A novel variant in TAF1 affects gene expression and is associated with X-linked TAF1 intellectual disability syndrome
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Includes: Supplementary data
Articles

A role for viral infections in Parkinson’s etiology?

Laura K. Olsen, Eilis Dowd, Declan P. McKernan
Journal: Neuronal Signaling
Neuronal Signal (2018) 2 (2): NS20170166.
https://doi.org/10.1042/NS20170166
Published: 16 April 2018
View article titled, A role for viral infections in Parkinson’s etiology?
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Articles

Inhibition of miR-181a promotes midbrain neuronal growth through a Smad1/5-dependent mechanism: implications for Parkinson’s disease

Shane V. Hegarty, Aideen M. Sullivan, Gerard W. O’Keeffe
Journal: Neuronal Signaling
Neuronal Signal (2018) 2 (1): NS20170181.
https://doi.org/10.1042/NS20170181
Published: 26 January 2018
View article titled, Inhibition of miR-181a promotes midbrain neuronal growth through a Smad1/5-dependent mechanism: implications for Parkinson’s disease
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Articles

SUMOylation and calcium signalling: potential roles in the brain and beyond

Leticia Coelho-Silva, Gary J. Stephens, Helena Cimarosti
Journal: Neuronal Signaling
Neuronal Signal (2017) 1 (3): NS20160010.
https://doi.org/10.1042/NS20160010
Published: 19 July 2017
View article titled, SUMOylation and calcium signalling: potential roles in the brain and beyond
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Articles

Conventional protein kinase C in the brain: 40 years later

Julia A. Callender, Alexandra C. Newton
Journal: Neuronal Signaling
Neuronal Signal (2017) 1 (2): NS20160005.
https://doi.org/10.1042/NS20160005
Published: 10 April 2017
View article titled, Conventional protein kinase C in the brain: 40 years later
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Articles

AMPK: keeping the (power)house in order?

Claire Thornton
Journal: Neuronal Signaling
Neuronal Signal (2017) 1 (2): NS20160020.
https://doi.org/10.1042/NS20160020
Published: 24 March 2017
View article titled, AMPK: keeping the (power)house in order?
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Articles

Glycinergic transmission: glycine transporter GlyT2 in neuronal pathologies

Francisco Zafra, Ignacio Ibáñez, Cecilio Giménez
Journal: Neuronal Signaling
Neuronal Signal (2017) 1 (1): NS20160009.
https://doi.org/10.1042/NS20160009
Published: 22 December 2016
View article titled, Glycinergic transmission: glycine transporter GlyT2 in neuronal pathologies
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