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Cover ImageThe picture represents well known brain-to-body cholinergic anti-inflammatory pathway: acetylcholine (ACh, red sphere) released from the vagus nerve (representative cholinergic neuron depicted in red) stimulates production of norepinephrine (green sphere) in the splenic nerve that triggers release of ACh from a splenic T cell and subsequent activation of anti-inflammatory secondary signaling mechanisms (including NF-κB, JAK-STAT pathways, etc.) in splenic macrophages via stimulation of the α7 nicotinic acetylcholine receptor (α7 nAChR, red receptor) resulting in lower production of pro-inflammatory cytokines (TNFα, IL-1β, IL-6, IL-8). This circuit is activated by pro-inflammatory cytokines at the sensory fibers of the vagus nerve, and the related neuroinflammation process involves interaction of cholinergic neurons with microglia, astrocytes, oligodendrocytes, and dendritic cells in the brain.Close Modal
In this Issue
Cholinergic blockade of neuroinflammation: from tissue to RNA regulators
Neuronal Signal (2022) 6 (1): NS20210035.
Cell models for Down syndrome-Alzheimer’s disease research
Neuronal Signal (2022) 6 (1): NS20210054.
Targeting the M1 muscarinic acetylcholine receptor in Alzheimer’s disease
Neuronal Signal (2022) 6 (1): NS20210004.
Sex-dependent effects of chronic exercise on cognitive flexibility but not hippocampal Bdnf in aging mice
Neuronal Signal (2022) 6 (1): NS20210053.
Neuroprotection of retinal ganglion cells in vivo using the activation of the endogenous cannabinoid signaling system in mammalian eyes
Neuronal Signal (2022) 6 (1): NS20210038.