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Volume 3, Issue 2
June 2019
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    In the latest issue of Neuronal Signaling (volume 3, issue 2), White et al. test the therapeutic efficacy of modulating collapsin response mediator protein 2 (CRMP2) activity via S-N-benzy-2-acetamido-3-methoxypropionamide ((S)-Lacosamide) on CLN6-Batten disease - a rare neurodegenerative disorder with no current cure. This cover features a representative image from their study, depicting classic Batten disease pathology in Cln6 mutant mouse brains.
EISSN 2059-6553
In this Issue

Review Article

The role of APOE4 in Alzheimer’s disease: strategies for future therapeutic interventions
Holly C. Hunsberger; Priyanka D. Pinky; Warren Smith; Vishnu Suppiramaniam; Miranda N. Reed
Neuronal Signal (2019) 3 (2): NS20180203.
View Articletitled, The role of APOE4 in Alzheimer’s disease: strategies for future therapeutic interventions
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Commentaries

The orphan nuclear receptor TLX: an emerging master regulator of cross-talk between microglia and neural precursor cells
Paul J. Lucassen; Anne-Marie van Dam; Prasanna Kandel; Pascal Bielefeld; Aniko Korosi; Carlos P. Fitzsimons; Mirjana Maletic-Savatic
Neuronal Signal (2019) 3 (2): NS20180208.
View Articletitled, The orphan nuclear receptor TLX: an emerging master regulator of cross-talk between microglia and neural precursor cells
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Research Articles

Modulation of CRMP2 via (S)-Lacosamide shows therapeutic promise but is ultimately ineffective in a mouse model of CLN6-Batten disease
Katherine A. White; Jacob T. Cain; Helen Magee; Seul Ki Yeon; Ki Duk Park; Rajesh Khanna; Jill M. Weimer
Neuronal Signal (2019) 3 (2): NS20190001.
View Articletitled, Modulation of CRMP2 via (<em>S</em>)-Lacosamide shows therapeutic promise but is ultimately ineffective in a mouse model of CLN6-Batten disease
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Culturing primary neurons from rat hippocampus and cortex
Madhusmita Priyadarshini Sahu; Outi Nikkilä; Seija Lågas; Sulo Kolehmainen; Eero Castrén
Neuronal Signal (2019) 3 (2): NS20180207.
View Articletitled, Culturing primary neurons from rat hippocampus and cortex
Supplementary data
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Modelling Alzheimer’s disease in a dish: dissecting amyloid-β metabolism in human neurons
Cytokine activity in Parkinson’s disease
Inflammation and emotion regulation: a narrative review of evidence and mechanisms in emotion dysregulation disorders
Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-β deposition
Modeling Parkinson’s disease in LRRK2 rodents
  • Online ISSN 2059-6553

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