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April 2017
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Cover Image
Cover Image
This figure depicts the priming, activation, and deactivation life-cycle of a conventional protein kinase C (PKC). PKC signaling is controlled by a highly regulated series of conformational changes. Deregulation of any of the steps in this finely-tuned pathway results in pathophysiologies. For further details, see the Callender and Newton article in this issue of Neuronal Signaling that provides an overview of signaling by diacylglycerol-dependent PKC isozymes in the brain, with a focus on the role of the Ca2+-sensitive conventional PKC isozymes in neurodegeneration. Image kindly provided by Alexandra C Newton, University of California at San Diego.
EISSN 2059-6553
In this Issue
Review Articles
Targeting bone morphogenetic protein signalling in midbrain dopaminergic neurons as a therapeutic approach in Parkinson's disease
Neuronal Signal (2017) 1 (2): NS20170027.