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Keywords: unfolded protein response
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Essays Biochem (2017) 61 (6): 625–635.
Published: 12 December 2017
... the ER lumen. Signalling sensors within the ER detect perturbations within the lumen (ER stress) and employ downstream signalling cascades that engage effector mechanisms to restore homeostasis. The most studied signalling mechanism that the ER employs is the unfolded protein response (UPR), which...
Essays Biochem (2016) 60 (2): 133–142.
Published: 15 October 2016
...-shock response protein-misfolding diseases proteostasis stress responses systemic proteostasis transcellular chaperone signalling unfolded protein response Whereas transcellular chaperone signalling can be activated from the neurons to induce cell-non-autonomous adjustment of hsp90...