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Keywords: ubiquitin ligases
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Essays Biochem (2022) 66 (2): 99–110.
Published: 05 August 2022
...Carla Brillada; Marco Trujillo Most research in the field of ubiquitination has focused on E3 ubiquitin ligases because they are the specificity determinants of the ubiquitination process. Nevertheless, E2s are responsible for the catalysis during ubiquitin transfer, and are therefore, at the heart...
Includes: Supplementary data
Essays Biochem (2022) 66 (2): 135–145.
Published: 05 August 2022
... severely affects growth, development and responses to stress. The activity of E3 ubiquitin ligases marks proteins fated for degradation with chains of the post-translational modifier, ubiquitin. Proteasomal processing of ubiquitinated substrates involves ubiquitin chain recognition, deubiquitination, ATP...
Essays Biochem (2022) 66 (2): 123–133.
Published: 05 August 2022
... of environmental stress. A key component of the UPS are ubiquitin ligases (or E3s) that catalyze the attachment of ubiquitin molecules to select substrate proteins, which are then recognized by the 26S proteasome for degradation. With the identification of substrate proteins, a growing number of E3s are shown...
Essays Biochem (2020) 64 (5): 807–817.
Published: 29 July 2020
... by a large E3 ubiquitin ligase complex called the FA core complex. Mutations in FANCD2, FANCI or FA core complex components cause the FA bone marrow failure syndrome. Despite the importance of these proteins to DNA repair and human disease, our molecular understanding of the FA pathway has been limited due...
Essays Biochem (2017) 61 (5): 517–527.
Published: 02 October 2017
... 2017 15 09 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 Protein degradation PROTAC proteasomes ubiquitins ubiquitin ligases Drug discovery scientists today face a number of challenges in two key areas: (i...