...Samrat Mukhopadhyay; Kurtis Mengham; Youssra Al-Hilaly; Sebastian Oakley; Kamillia Kasbi; Mahmoud B. Maina; Louise C. Serpell Tau is an intrinsically disordered protein that has the ability to self-assemble to form paired helical and straight filaments in Alzheimer’s disease, as well as the ability...

... Lewy body dementia MT microtubule MTBD microtubule-binding domain NFT neurofibrillary tangle PD Parkinson's disease PSP progressive supranuclear palsy References 1. Lewis J. and Dickson D.W. ( 2016 ) Propagation of tau pathology: hypotheses...

... the cytoplasmic protein tau aggregates in neurons, and also, in some diseases, in glia. Animal models have sought to distil the contribution of tau aggregation to the cell death process but despite intensive research, no one mechanism of cell death has been unequivocally defined. The process of tau aggregation...

...Sarah Perrett; Jian-Zhi Wang; Xinya Gao; Zhi-Hao Wang Tau belongs to the family of microtubule-associated proteins predominantly expressed in neurons where they play an important role in promoting microtubule assembly and stabilizing microtubules. In addition, tau proteins interact with other...