... Press Limited on behalf of the Biochemical Society 2021 metabolic engineering recombinant proteins synthetic biology systems biology yeast Several well-established molecular biology techniques in P. pastoris aid in speeding up the strain generation process ( Figure 2...

... Society 2018 Systems Biology Integrative workflows Network analysis Disease signatures Therapeutic targets Technological advances generate a remarkable variety of data to characterize the components of molecular and cellular systems. When we started our work in cancer systems biology 20...

...Walter Kolch; Dirk Fey; Colm J. Ryan In this issue of Essays in Biochemistry , biochemistry meets systems biology—a blind date that may hold all the promises, pitfalls and failures of a relationship where a new discipline has been sprung upon a well-established one. As the articles in this issue...

...Iman Tavassoly; Joseph Goldfarb; Ravi Iyengar Systems biology is an integrative discipline connecting the molecular components within a single biological scale and also among different scales (e.g. cells, tissues and organ systems) to physiological functions and organismal phenotypes through...

... the necessary sensitivity, selectivity, and spatial resolution to usefully probe heterocellular signaling processes, but these are best used to test specific, mechanistic models. Decades of systems biology research with monocultures has provided a solid foundation for building models of heterocellular signaling...

... G. Albeck ( jgalbeck@ucdavis.edu ) extracellular signal-regulated kinases imaging techniques receptor tyrosine kinases systems biology transcription 05 06 2018 10 08 2018 14 08 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf...

... BY) . biological networks intracellular signaling phosphorylation/dephosphorylation systems biology Cells transduce and integrate environmental stimuli through a variety of intracellular signalling mechanisms in order to generate appropriate and timely physiological responses. The reversible...

... profiling has the potential to help identify the underlying causal mechanisms that link genotype to phenotype. We present a brief review of proteomics and metabolomics in ageing research with a focus on the potential of a systems biology and network-centric perspective in geroscience. While network analyses...

... Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . aging cell homeostasis systems biology Computational models have been developed to study individual mechanisms in the context of ageing [ 2 ]. Many other models have been developed outside this context...