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Keywords: proteostasis
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Articles
Essays Biochem (2022) 66 (2): 219–228.
Published: 05 August 2022
...Ernesto Llamas; Pablo Pulido Several protein homeostasis (proteostasis) pathways safeguard the integrity of thousands of proteins that localize in plant chloroplasts, the indispensable organelles that perform photosynthesis, produce metabolites, and sense environmental stimuli. In this review, we...
Articles
Essays Biochem (2022) 66 (2): 147–154.
Published: 05 August 2022
...Michael J. Skelly Proper regulation of protein homeostasis (proteostasis) is essential for all organisms to survive. A diverse range of post-translational modifications (PTMs) allow precise control of protein abundance, function and cellular localisation. In eukaryotic cells, ubiquitination...
Articles
Essays Biochem (2022) 66 (2): 243–253.
Published: 05 August 2022
... and applications of this information to accelerate modern agriculture breeding programmes and optimize energy use efficiency in proteostasis. Correspondence: A. Harvey Millar ( harvey.millar@uwa.edu.au ) 09 02 2022 07 06 2022 27 06 2022 © 2022 The Author(s). 2022 This is an open...
Articles
Essays Biochem (2022) 66 (2): 75–85.
Published: 05 August 2022
... in recent years, through the development and application of powerful technologies including genome sequencing, a pantheon of ‘omics techniques, precise genome editing, and step changes in structural biology and microscopy. Proteostasis – the collective processes that control the protein complement...
Articles
Essays Biochem (2017) 61 (6): 625–635.
Published: 12 December 2017
... . Nat. Cell Biol. 18 , 1173 – 1184 69 Smith M.D. , Harley M.E. , Kemp A.J., Wills, J., Lee, M., Arends, M. et al. ( 2017 ) CCPG1, a non-canonical autophagy cargo receptor essential for pancreatic ER proteostasis . Dev. Cell. , in press 70 Yang H. , Ni H.M...
Articles
Essays Biochem (2016) 60 (2): 153–161.
Published: 15 October 2016
... proteasome protein quality control proteostasis In order to fulfil their physiological functions, proteins need to fold into their unique three-dimensional structure. Even correctly folded proteins are constantly challenged by the cellular environment and are prone to unfolding or aggregation...
Articles
Essays Biochem (2016) 60 (2): 133–142.
Published: 15 October 2016
... discuss emerging insights and provide specific examples on how components of the cell-non-autonomous proteostasis network are used in cancer and protein-folding diseases to drive disease progression across tissues. cancer cell-non-autonomous heat-shock response protein-misfolding diseases...
Articles
Essays Biochem (2016) 60 (2): 173–180.
Published: 15 October 2016
...Patricija van Oosten-Hawle; Matthew P. Jackson; Eric W. Hewitt Proteostasis refers to the regulation of the cellular concentration, folding, interactions and localization of each of the proteins that comprise the proteome. One essential element of proteostasis is the disposal of misfolded proteins...
Articles
Essays Biochem (2016) 60 (2): 143–151.
Published: 15 October 2016
...Patricija van Oosten-Hawle; John S. Bett Cells have developed an evolutionary obligation to survey and maintain proteome fidelity and avoid the possible toxic consequences of protein misfolding and aggregation. Disturbances to protein homoeostasis (proteostasis) can result in severe cellular...
Articles
Essays Biochem (2016) 60 (2): 181–190.
Published: 15 October 2016
... disaggregation protein homoeostasis protein-misfolding disorders proteostasis proteotoxicity Multiple proteins have the intrinsic ability to misfold and convert from a soluble into an alternative conformation, which can form amyloids, infamous protein aggregates, associated with a specific subgroup...
Articles
Essays Biochem (2016) 60 (2): 191–202.
Published: 15 October 2016
... of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY) . ageing epigenetics proteostasis transgenerational epigenetic inheritance Protein homoeostasis (proteostasis) has been defined as the state in which the proteome is kept in functional balance...
Articles
Essays Biochem (2016) 60 (2): 237–253.
Published: 15 October 2016
... proteostasis sHsp Although all chaperonins share a common cylindrical architecture, substantial structural differences exist between group I and group II members. Whereas group II chaperonins share a similar monomer and cylindrical organization to that of GroEL, their rings are mostly composed...
Articles
Essays Biochem (2014) 56: 53–68.
Published: 18 August 2014
...) protein aggregation protein folding proteostasis The native state of functional proteins is a delicate, flexible and, in many cases, metastable conformation. Spontaneous folding to this native state was demonstrated in the early 1960s, when denatured proteins were successfully refolded...