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Keywords: proteostasis
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Essays Biochem (2022) 66 (2): 243–253.
Published: 05 August 2022
... and applications of this information to accelerate modern agriculture breeding programmes and optimize energy use efficiency in proteostasis. Correspondence: A. Harvey Millar ( harvey.millar@uwa.edu.au ) 09 02 2022 07 06 2022 27 06 2022 © 2022 The Author(s). 2022 This is an open...
Articles
Essays Biochem (2022) 66 (2): 75–85.
Published: 05 August 2022
... in recent years, through the development and application of powerful technologies including genome sequencing, a pantheon of ‘omics techniques, precise genome editing, and step changes in structural biology and microscopy. Proteostasis – the collective processes that control the protein complement...
Articles
Essays Biochem (2022) 66 (2): 219–228.
Published: 05 August 2022
...Ernesto Llamas; Pablo Pulido Several protein homeostasis (proteostasis) pathways safeguard the integrity of thousands of proteins that localize in plant chloroplasts, the indispensable organelles that perform photosynthesis, produce metabolites, and sense environmental stimuli. In this review, we...
Articles
Essays Biochem (2022) 66 (2): 147–154.
Published: 05 August 2022
...Michael J. Skelly Proper regulation of protein homeostasis (proteostasis) is essential for all organisms to survive. A diverse range of post-translational modifications (PTMs) allow precise control of protein abundance, function and cellular localisation. In eukaryotic cells, ubiquitination...
Articles
Essays Biochem (2017) 61 (6): 625–635.
Published: 12 December 2017
... BY) . Autophagy ER-phagy ER stress ER homeostasis proteostasis unfolded protein response The endoplasmic reticulum (ER) is an intracellular organelle that consists of a continuous network of membranous sheets and tubules spanning the cytoplasm. A lipid bilayer segregates the ER lumen from the cytosol...
Articles
Essays Biochem (2016) 60 (2): 153–161.
Published: 15 October 2016
... proteasome protein quality control proteostasis In order to fulfil their physiological functions, proteins need to fold into their unique three-dimensional structure. Even correctly folded proteins are constantly challenged by the cellular environment and are prone to unfolding or aggregation...
Articles
Essays Biochem (2016) 60 (2): 173–180.
Published: 15 October 2016
...Patricija van Oosten-Hawle; Matthew P. Jackson; Eric W. Hewitt Proteostasis refers to the regulation of the cellular concentration, folding, interactions and localization of each of the proteins that comprise the proteome. One essential element of proteostasis is the disposal of misfolded proteins...
Articles
Essays Biochem (2016) 60 (2): 143–151.
Published: 15 October 2016
...Patricija van Oosten-Hawle; John S. Bett Cells have developed an evolutionary obligation to survey and maintain proteome fidelity and avoid the possible toxic consequences of protein misfolding and aggregation. Disturbances to protein homoeostasis (proteostasis) can result in severe cellular...
Articles
Essays Biochem (2016) 60 (2): 191–202.
Published: 15 October 2016
... lifespan-extending metabolic shifts. Therefore a likely possibility is that the epigenetic memory activated in the ancestors targets at least part of these pro-longevity metabolic pathways. Only a few studies have directly investigated transgenerational inheritance in the context of proteostasis. Do all...
Articles
Essays Biochem (2016) 60 (2): 133–142.
Published: 15 October 2016
... discuss emerging insights and provide specific examples on how components of the cell-non-autonomous proteostasis network are used in cancer and protein-folding diseases to drive disease progression across tissues. * Correspondence: Patricija van Oosten-Hawle (email p.vanoosten-hawle@leeds.ac.uk...
Articles
Essays Biochem (2016) 60 (2): 181–190.
Published: 15 October 2016
... anticipated [ 13 ]. Cells have evolved a sophisticated protein quality control system to counteract protein aggregation and to ensure protein homoeostasis (proteostasis) [ 14 ]. Molecular chaperones are central components of this proteostasis network as they contribute to all aspects of proteome...
Articles
Essays Biochem (2016) 60 (2): 237–253.
Published: 15 October 2016
... 2016 C. elegans chaperone folding heat shock proteins (Hsp) Hsp100 Hsp60 Hsp70 Hsp90 proteostasis sHsp Figure 1 Co-chaperones regulate the function of molecular chaperones The ATPase chaperones are assisted by diverse groups of co-chaperones. Co-chaperone function can...
Articles
Essays Biochem (2014) 56: 53–68.
Published: 18 August 2014
... of these diseases and provide potential targets for therapy. It is necessary that cells continuously safeguard the functionality of their proteins and the general protein homoeostasis, termed proteostasis [ 8 , 9 ]. This is challenging even during normal growth periods, but in particular after exposure...