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Keywords: protein misfolding
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Essays Biochem (2022) 66 (7): 1001–1011.
Published: 16 December 2022
... of neurodegenerative diseases, it remains unclear how tau is involved in disease causation and progression and what may trigger protein misfolding. One potential area of interest is liquid–liquid phase separation (LLPS) where tau may be present at higher concentrations and this could give rise to the ideal conditions...
Essays Biochem (2016) 60 (2): 173–180.
Published: 15 October 2016
..., in which proteins misfold, forming amyloid deposits that are not degraded effectively by cells. Amyloid may then exacerbate this failure by disrupting autophagy and lysosomal proteolysis. However, targeting the pathways that regulate autophagy and the biogenesis of lysosomes may present approaches that can...
Essays Biochem (2016) 60 (2): 143–151.
Published: 15 October 2016
...Patricija van Oosten-Hawle; John S. Bett Cells have developed an evolutionary obligation to survey and maintain proteome fidelity and avoid the possible toxic consequences of protein misfolding and aggregation. Disturbances to protein homoeostasis (proteostasis) can result in severe cellular...
Essays Biochem (2016) 60 (2): 203–212.
Published: 15 October 2016
... on behalf of the Biochemical Society 2016 cellular targeting proteasomes protein misfolding ribosomes In all living systems, ribosomes synthesize proteins by assembling amino acids in a stepwise manner from the N-terminus towards the C-terminus. During synthesis, the growing polypeptide...