... Society under a transformative agreement with JISC. Alzheimer's disease amyloid intrinsically disordered proteins liquid liquid phase separation protein misfolding tau Tau is a microtubule binding protein and an important component of the neuronal cytoskeleton as well as playing a role...

..., in which proteins misfold, forming amyloid deposits that are not degraded effectively by cells. Amyloid may then exacerbate this failure by disrupting autophagy and lysosomal proteolysis. However, targeting the pathways that regulate autophagy and the biogenesis of lysosomes may present approaches that can...

...Patricija van Oosten-Hawle; John S. Bett Cells have developed an evolutionary obligation to survey and maintain proteome fidelity and avoid the possible toxic consequences of protein misfolding and aggregation. Disturbances to protein homoeostasis (proteostasis) can result in severe cellular...

... on behalf of the Biochemical Society 2016 cellular targeting proteasomes protein misfolding ribosomes In all living systems, ribosomes synthesize proteins by assembling amino acids in a stepwise manner from the N-terminus towards the C-terminus. During synthesis, the growing polypeptide...