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Keywords: protein degradation
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Essays Biochem (2022) 66 (2): 179–188.
Published: 05 August 2022
... of the Biochemical Society 2022 ERAD plant biology protein degradation selective autophagy Endoplasmic reticulum (ER)-associated degradation (ERAD) is a mechanism that involves retrotranslocation of an ER luminal-localized or ER-membrane-anchored protein into cytosolic proteasomal degradation, which...
Essays Biochem (2022) 66 (2): 123–133.
Published: 05 August 2022
... 2022 11 05 2022 30 05 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 26S Proteasome Abiotic Stress Biotic Stress Protein degradation Ubiquitin ligases Ubiquitination Plant survival of adverse conditions entails...
Essays Biochem (2017) 61 (5): 505–516.
Published: 08 November 2017
...Rob L.M. van Montfort; Paul Workman; Scott J. Hughes; Alessio Ciulli Molecular glues and bivalent inducers of protein degradation (also known as PROTACs) represent a fascinating new modality in pharmacotherapeutics: the potential to knockdown previously thought ‘undruggable’ targets at sub...
Essays Biochem (2017) 61 (5): 517–527.
Published: 02 October 2017
.... Selective inhibitors are achievable for only a fraction of the proteome, and are not guaranteed to elicit the desired response in patients, especially when pursuing targets identified through genetic knockdown. Targeted protein degradation holds the potential to expand the range of proteins that can...
Essays Biochem (2016) 60 (2): 213–225.
Published: 15 October 2016
... of the Biochemical Society 2016 AAA ATP-dependent protease ClpP Hsp60 Hsp70 LON mitochondria mitochondrial unfolded protein response mitophagy molecular chaperones organellar quality control protein degradation protein folding protein quality control PQC mechanisms in mitochondria can...